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Saraf, Swarnlata
- Bioengineering Techniques for the Efficacy Studies of Herbal Cosmetics
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur- 492010 CG, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur- 492010 CG, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 1, No 1 (2010), Pagination: 1-12Abstract
Bioengineering techniques have turned the way of cosmetics evaluation towards the non-invasive direction. The numerical assessment of skin properties improvement sounds interesting to the consumers. Bioengineering techniques have attracted the minds of many researchers and beliefs of consumers towards cosmetic. Instruments developed under these techniques are harmless. These techniques are fruitful not only for the cosmetics evaluation but also for comparative studies and for treatment of diseases. In efficacy studies of cosmetics, of particular importance is the epidermis, its water content, its composition, and its barrier function. It facilitates the quantitative evaluation of moisturizers, fairness creams, sun protection creams, anti-aging products, scrubbers etc.Keywords
Bioengineering Techniques, Instrumentations, Skin Firmness, Skin Hydration, Skin Color, Barrier Function, Wrinkles, Sebum Level, and Microcirculation.
- Formulation and Evaluation of Herbal Shampoo Containing Extract of Allium sativum
Abstract Views :202 |
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Authors
Affiliations
1 University Institute of pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) – 492010, IN
1 University Institute of pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) – 492010, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 2, No 1 (2011), Pagination: 18-20Abstract
Allium sativum, family Alliaceae possessess antixidant, antimicrobial, antitumour, antimutagenic, antiinflammatory, antiviral and antiulcer properties. The aim of this study was to take the benefit of the nature of A. sativum extract and prepare shampoo incorporating in the herbal constituent base and evaluate this natural herbal shampoo. The herbal shampoo formulations comprising of aqueous extract of Allium sativum (5% to 30% w/w), coconut oil, castor oil, olive oil, fragrance were prepared and evaluated for physicochemical parameters and the results showed the production of stable herbal shampoos. The pH (6.22 ± 0.01 to 5.01± 0.02), percentage of solids (23.21± 0.02 to 25.41± 0.04), , dirt dispersion, surface tension (37.25 ± 0.45 to 39.87 ± 0.15), viscosity (6.5±0.2 to 5.4±0.2 ), skin irritation test ( no irritation) and visual stability .Formulations were clear, had good foam formation, foam quality and retention with proper rheological properties and skin compliances. The formulations with 10 % extract showed best results of evaluation parameters. The efficacy was in the range 10 % extract containing shampoo (F2) >5 % extract containing shampoo (F1) > 20 % extract containing shampoo (F3)> 30 % extract containing shampoo (F4).Keywords
Allium sativum, Antimicrobial Herbal Shampoo, Natural Compositions.- HPTLC Method for Routine Quality Control of Ayurvedic Formulation Drakshadi Gutika
Abstract Views :225 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur (C.G.), 492 010, IN
2 Chhattisgarh Food and Drug Administration, Raipur (C.G.) 492 001, IN
1 University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur (C.G.), 492 010, IN
2 Chhattisgarh Food and Drug Administration, Raipur (C.G.) 492 001, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 4 (2013), Pagination: 111-114Abstract
The Drakshadi gutika is effective for amlapitta (hyperacidity), hrddaha (heart disease), kanthadaha (itching of throat), trsna (thirst), murccha (syncope), agnimandaya (digestive impairment), bhrama (vertigo) and amavata (rheumatism) is official in Ayurveduc formulary in India. Quantification of active principles through modern analytical tools is essential for establishing the authenticity, creditability, prescription and usage of Ayurvedic medicines/herbal formulations. The Ayurvedic formulation Drakshadi gutika has been prepared as per Ayurvedic formulary of India was estimated HPTLC for its gallic acid content. Three-laboratory batch of Drakshadi gutika were estimated for their gallic acid contents against standard gallic acid solution. The method was validated for linearity, accuracy, limit of detection, limit of quantification, inter-day and intra-day assay precision, repeatability of measurement, and repeatability of sample application. The concentration of gallic acid present in raw material was found to be 8.912±0.41w/w in Terminalia belerica, and 0.73±0.63 w/w in vitis vinifera and in three identical laboratory batch of Drakshadi gutika DG-I, DG-II and DG-III, was found to be 3.307±0.52, 3.301±0.63%, 3.314±0.35 w/w respectively. The gallic acid content in all the three different batches is found to be in close proximities with each other. The results were comparable to marketed formulations. Hence the present method is simple, sensitive, precise and accurate and can be adopted for routine quality control of Drakshadi gutika.Keywords
Gallic acid, Drakshadi gutika, HPTLC, Fingerprinting, Ayurvedic formulation, Quality control parameter.- Simple and Rapid Spectrofluorometric Fingerprint Development of Quinine in Unani Formulation
Abstract Views :212 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (Chhattisgarh)- 492010, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (Chhattisgarh)- 492010, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 14-17Abstract
A simple, precise and accurate spectrofluorometric method has been established for quantitative determination of quinine. Conditions were also optimized for best possible extraction of quinine via varying concentrations of different solvents for maximum recovery of quinine at excitation wavelength 372 nm and emission wavelength 456 nm. Methanol found to be best for highest possible recovery of target analyte quinine. The linear range of 1.0- 7.0 μg/mL was obtained for quinine. The detection limit was 0.1768 and quantitation limit was found to be 0.5411for quinine. The recovery of the quinine was found to be 97.35-99.85 %. The proposed method was used for the determination of quinine alkaloids in pharmaceuticals and herbal formulations with satisfactory result.
Keywords
Unani Medicine, Validation, Spectrofluorometer, Quinine.- TLC Densitometry Method for Determination of Cinnamaldehyde in a Traditional Indian Formulation
Abstract Views :176 |
PDF Views:0
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh 492010, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh 492010, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1953-1956Abstract
A new, simple, sensitive, selective, precise and robust high-performance thin-layer chromatographic (HPTLC) method developed and validated for the determination of Cinnamaldehyde in Indian traditional formulation (sitopaladi churna) and crude drug extracts. Analysis was performed on TLC aluminium plates pre-coated with silica gel 60F-254 as the stationary phase. Linear ascending development was carried out in twin trough glass chamber saturated with mobile phase consisting of Toluene: Ethyl acetate: Methanol (8:1:1) at room temperature (25±2°C). Camag TLC scanner III was used for spectrdensitometric scanning and analysis in absorbance mode at 295 nm. The system was found to give compact spots for Cinnamaldehyde (Rf value of 0.55±0.02). The linear regression analysis data for the calibration plots showed good linear relationship (r2 = 0.996±0.0003) in the concentration range 200-1200 ng spot−1 with respect to peak area. According to the International Conference on Harmonization (ICH) guidelines, the method was validated for precision, recovery, robustness and ruggedness. The limits of detection and quantification were determined. The Cinnamaldehde content was quantified and estimated from the formulation and the cinnamomum zeylanicum plant part. Statistical analysis of the data showed that the method is reproducible and selective for the quantitatve determination of Cinnamaldehyde.Keywords
Cinnamaldehyde, High-Performance Thin Layer Chromatography, Indian Traditional Formulation, Quantitative Analysis.- HPLC Determination of Piperine in ‘Trikatu Churna’ a Potent Ayurvedic Formulation for Routine Quality Control
Abstract Views :194 |
PDF Views:1
Authors
Affiliations
1 Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (CG), IN
1 Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (CG), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 183-186Abstract
Quantification of active principles through modern analytical tools is essential for establishing the authenticity, creditability, prescription and usage of Ayurvedic medicines/herbal formulations. ‘Trikatu churna’ is one of the oldest and popular Ayurvedic preparations, is official in Ayurvedic formulary of India used widely for disorder of respiratory tract and digestive system. It comprised of the fruits Piper longum (Pippali), Piper nigrum (Marica) and rhizomes of Zingiber officianalis (Saunth). The present study is an attempt to develop the fingerprint method for Trikatu Churna by simple high-performance liquid chromatography (HPLC) determination using Piperine as a standard, which is as an important and major content in formulation. RP- HPLC methods for determination of Piperine from the fruits of Pippali, Marica and Trikatu Churna have been developed. A C 18 LUNA (5 micron 25 cm×4.6 mm) column from Phenomenex in binary gradient mode with mobile phase methanol at flow rate is 1.0ml/min, and effluent was monitored at 342 nm. Validation of the method was done with a view to demonstrate its selectivity, linearity, precision and accuracy. The concentration of Piperine present in raw material was found to be 4.1%± 0.42w/w in marica, and 2.05% ± 0.39w/w in pippali respectively and in three identical laboratory batch of Trikatu Churna name TK-I, TK-II, TK-III, was 2.02%±0.61, 2.23%±0.49, 2.21%±0.53w/w respectively with mean value 2.15%±0.54w/w. The Piperine content of all the three batches is found to be in close proximities with each other. Obtained results were compared with marketed formulations.
Keywords
Piperine, Trikatu Churna, HPLC, Ayurvedic Formulation, Fingerprinting.- The Potentials of Dehydroepiandrosterone (DHEA) in Skin Ageing Process
Abstract Views :196 |
PDF Views:1
Authors
Affiliations
1 University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, IN
2 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Dist-Durg, C.G, IN
1 University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, IN
2 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Dist-Durg, C.G, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 4, No 2 (2013), Pagination: 43-47Abstract
Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.Keywords
DHEA, Testosterone, Estrogen, Targeted Drug Delivery.- Formulation and Evaluation of Pulsatile Drug Delivery System of Ramipril for Controlling Morning Spate of B.P.
Abstract Views :247 |
PDF Views:85
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, IN
Source
Journal of Pharmaceutical Research, Vol 17, No 1 (2018), Pagination: 2-12Abstract
The aim of the study was to design pulsatile release capsule of Ramipril. Plasma norepinephrine level and plasma renin activity are elevated in the morning; both hormones have potential to induce coronary vasoconstriction, therefore, we can achieve peak plasma concentration of drug at morning and can control morning spate of B.P. compliances. The rapid release of the drug after a lag time consistent with the requirement for chronotherapeutics was achieved with developed formulation M-6 (swellable polymer; xanthan gum, core tablet; C-2, erodible tablet; E-2 and 10 % w/w coated capsule body) which show lag time of 4 hr. During the lag time, only 25 % drug released following rapid release (99.13 ± 83 % in 7 hr.) of the drug was observed. The ex-vivo absorption study conducted using everted chicken intestinal segment indicated a delay in absorption of the drug. Thus this approach can provide a useful means for timed release of Ramipril and may be helpful for patients with morning spate of BP.Keywords
Chronotherapeutics, Ramipril, Pulsatile Delivery, Swelling Control.Full Text
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